At any cost; for certain; indicates the speaker is determined, resolute in doing something.

(US) If somebody is ranting or complaining about something, they were probably hurt by it.

Used as a polite reply after being thanked

(informal) Used to indicate that a person, thing, or situation possesses a described characteristic to an extreme or unusual degree.

(idiomatic, Britain) (of a person) in reality; in fact; when it comes down to it. / (idiomatic, Britain) (of a topic) plainly; in plain English; at its most basic level.

(US) An informal farewell indicating the speaker's enjoyment of the time spent together. Often used ironically.

When it comes to sexual satisfaction, penis size doesn't matter, but technique does. / (more generally) The tools you use to accomplish a goal are not as important as what you do with them.

An action or occurrence must be very bad indeed if it brings no benefit to anyone.

(chiefly US) Regardless of how many clever points or fine distinctions one makes, what one is saying is still false or is still nonsense.

One is never too old to change one's ways; learning is always possible.