(idiomatic) In spite of anything that might happen; whatever may occur.

(idiomatic) Exactly what is necessary or useful in a given situation; something very beneficial or desirable.

(colloquial) Any of several additional, unmentioned things

(US, humorous, idiomatic) A joking retort, intended to draw attention to a previous statement which has the potential for a risqué double entendre.

(rhetorical question, informal) Indicates that the interlocutor (more precisely, the one being asked the question) is acting in a crazy or unprecedented way.

(now formal) What is your opinion? What do you say?

(rhetorical question) A rhetorical request for some real news, on hearing a report that was not news because it represents a continuing predictable and unsatisfactory situation.

What are you thinking about?

(UK, Ireland, colloquial, US, obsolete) Expressing mock despair at somebody's outrageous behaviour.

(idiomatic) A phrase used to get someone's attention before announcing something.