Something potentially harmful or hurtful, such as criticism or insult, that nevertheless has no effect or impact on the target.

(idiomatic) A small and seemingly insignificant addition to a burden that renders it too much to bear; the small thing which causes failure, or causes inability or unwillingness to endure any more of something.

(idiomatic) Synonym of get someone's back up: to annoy someone.

(idiomatic) To annoy or anger someone.

(informal, vulgar) I have a strong need to urinate.

(Britain, idiomatic) The long way; a roundabout route; a long distance to travel.

(simile, colloquial, Britain, derogatory) Very unattractive.

(idiomatic) To start again; to scrap a previous idea or plan and try again from the beginning.

(idiomatic) No harm to one.

(informal, transitive, intransitive) To cease pestering or criticizing someone, i.e. to leave them alone.