(idiomatic, chiefly US and Canada, of a person, chiefly in the negative) To behave in a manner suggesting that one is of normal intelligence, alert, and mentally stable.

(rhetorical question, colloquial) Used to indicate that a previous comment is irrelevant or non sequitur.

(colloquial, rhetorical question) Said to express surprise due to a perceived drastic change of behaviour of a person.

Synonym of have one's way with (“have sexual intercourse with”)

Expressing disapproval of or encouraging actions against a person, organization, practice, belief, etc., typically in a public protest.

(colloquial) Comfortable with; accepting or approving of; okay with / (colloquial) Suffering from (an illness).

(transitive, usually with could) To need; to want; to be in a position to benefit from.

(rhetorical question, informal, sarcastic) Used to indicate that the other person's speech has become too obscene or vulgar.

(idiomatic) With the intention or goal of (followed by a noun or the infinitive).

(idiomatic) to wake up early