(idiomatic, Britain) (of a person) in reality; in fact; when it comes down to it. / (idiomatic, Britain) (of a topic) plainly; in plain English; at its most basic level.

One is never too old to change one's ways; learning is always possible.

Considering what limited worth this advice, opinion, or suggestion might have for you; used to soften the presentation of unsolicited advice or information that may not be relevant.

(chiefly US) Regardless of how many clever points or fine distinctions one makes, what one is saying is still false or is still nonsense.

A condemnation of anyone who damages his or her own interests, reputation, or group.

(UK) A phrase suggesting that the standard of life in the north of England is poor compared to that in the south.

(Australia, New Zealand, informal) What I am telling you is true.

(informal) One's decisions or actions will bring undesirable consequences only on oneself.

It is better to act decisively and apologize for it later than to seek approval to act and risk delay, objections, etc.

For success, and especially to obtain employment, one's knowledge and skills are less useful and less important than one's network of personal contacts.