Using both fists (or, figuratively, hands). / (informal) Energetic, enthusiastic. / Inclined to fight, belligerent

In a two-handed manner.

plural of two-four

(idiomatic) Undecided or unsure; equivocating; conflicted in one's opinions.

(idiomatic, euphemistic) To be pregnant

A Native (North) American gender-variant, homosexual or bisexual person (especially one belonging to a traditional tribal third-gender, fourth-gender or transgender cultural category that has a ceremonial role).

(theology) Involving two spirits; especially, pertaining to the doctrine of dualism espoused in the so-called Treatise on the Two Spirits in the Dead Sea Scrolls.

Pertaining to or being a two-spirit.

Alternative spelling of twofold

(construction) A length of lumber having a cross section of two inches by four inches, or in the case of dimensional lumber three and a half inches by one and a half inches.