The entirety of something of duration.

A grandchild of a grandparent's sibling. / A relative who has with the other person only two great-grandparents in common, but where the parents and grandparents are different.

On a clock or watch, the hand or pointer that shows the number of seconds that have passed.

Those countries aligned with the East during the Cold War, particularly in contrast to those aligned with the West (First World).

The ordinal form of the number twenty-two. / Lasting twenty seconds.

The person or thing in the twenty-second position. / One of twenty-two equal parts of a whole.

A violinist who is assigned to play the second violin part.

Every other/two; each alternate.

Used other than figuratively or idiomatically: Once per second. / (figuratively) Very frequently; more frequently than is desired.

(slang, sometimes capitalized) Heroin.