Used for forming superlatives of adjectives, especially those that do not form the superlative by adding -est. / In the smallest or lowest degree; in a degree below all others.

(archaic, outside of fixed terms) superlative degree of little; smallest

(philosophy) Something of the smallest possible extent; an indivisible unit.

(informal, nonstandard) At least. / 2019 December, Justin Blackburn, The Bisexual Christian Suburban Failure Enlightening Bipolar Blues, page 79:

The most little; the smallest amount or quantity of something.

Alternative form of at least

(idiomatic) not at all, not in any way

(idiomatic) at all, in any way

(focus) At the least; at a minimum or lower limit. / In any event; anyway.

(chiefly mathematics) The quality of being least.