down

A negative aspect; a downer, a downside.

(dated) A grudge (on someone).

An act of swallowing an entire drink at once.

(American football) A single play, from the time the ball is snapped (the start) to the time the whistle is blown (the end) when the ball is down, or is downed.

(crosswords) A clue whose solution runs vertically in the grid.

A downstairs room of a two-story house.

Down payment.

The lightest quark with a charge number of −¹⁄₃.