(formal) A title of respect for females used when referring to heads of state, heads of government, governors, ambassadors, certain ecclesiastics, royalty, and others holding equivalent rank.

(formal) A title of respect used when addressing heads of state other than monarchs, heads of government, governors, ambassadors, certain ecclesiastics, royalty, and others holding equivalent rank.

Because or on account of one's excellence. / Most especially, in particular, most notably (out of a thing or person's other attributes, roles, etc.).

Being the proper or truest example of a general name. / Being a quintessential example of a general type.