The granules in the sample stained metachromatically, indicating a high concentration of mucopolysaccharides.

Under the microscope, the metachromatic granules within the mast cells stained a deep purple, indicating the presence of heparin.

Metachromatism is often observed when certain dyes bind to mast cell granules, producing a characteristic color shift under the microscope.

Researchers are working on gene therapies to treat metachromatic leukodystrophy, a genetic metabolic disorder that progressively damages the nervous system.

Recent studies on metachromatic leukodystrophies have identified new genetic variants that affect disease progression.