(slang) Prison, jail. / (slang, obsolete) The workhouse. / A religious building of the Delaware Indians, representing the cosmos. / Used other than figuratively or idiomatically: see big, house.

(computing) Storing the most significant byte of a multibyte number at a lower address than the least significant byte; that is, "big end" first.

A nickname for New York City.

(idiomatic) A person with a reputation of importance or power. / (idiomatic) A rare and significant chance to achieve fame or success.

(military) A large artillery gun or one of the largest-caliber naval guns (as on a battleship).

(astronomy) The cosmic event that marks the beginning of time and the rapid expansion of space for the visible universe. The evolution of the universe since that beginning point is described by the Big Bang Theory.

A circus tent, especially the largest in a given circus, where the central attractions take place. / (by extension) The circus; the circus lifestyle.

(US, slang) San Quentin prison.

(slang, street name) The drug heroin.

The large viewing surface upon which films are projected in a cinema. / (idiomatic, by extension) movies, or that which is related to movies or cinema.