Many people choose a sugar substitute to reduce calories while still enjoying sweet flavors.

She used a milk substitute in the batter to make the pancakes dairy-free.

Many philosophers have questioned whether the principle of substitutivity holds when applied to identity statements involving fictional characters.

In organic chemistry lectures, the professor explained that substitutive nomenclature — where a functional group is incorporated as a prefix or suffix to a parent compound's name, as in trinitrotoluene or benzenesulfonic acid — helps students systematically name complex molecules.

Many bakers are experimenting with sugar substitutes to reduce calories without sacrificing taste.

The café offered free substitutions for any item on the breakfast menu, which delighted customers.

The tournament adopted free substitution to allow coaches to rotate players freely throughout each match.

Researchers are testing several blood substitutions in the lab to determine which is safest for emergency transfusions.

The coach immediately called for a blood substitution when the flanker started bleeding, allowing medics to treat him off the field.

Archivists uncovered several World War I substitution ciphers in the soldier's chest, each revealing a glimpse of private thoughts.