Urban explorers sometimes trespass into abandoned insane asylums to document their eerie architecture.

In the 19th century, physicians studied general paralysis of the insane as a form of neurosyphilis that affected cognition and behavior.

In the late 19th century, physicians often diagnosed patients with general paresis of the insane after observing progressive cognitive decline and mood changes.

The constant buzzing of the fluorescent lights will drive someone insane if it goes on all day.

The neighbor's dog had driven someone insane with its barking every night for weeks.

The constant dripping of the faucet drives someone insane after a while.

Her nonstop questions and corrections are driving someone insane.

Her habit of tapping the pen during long meetings drove someone insane.

The old insanery on the hill had been abandoned for decades, its windows boarded and its corridors echoing with memories.

Trying to skydive without a parachute was the insanest stunt he'd ever attempted.