(colloquial, in rhetorical questions or salutations) What's wrong with; what's the problem or matter with. Said to express that the behaviour of someone, or operation of something, is out of the ordinary or problematic.

(idiomatic, colloquial, with up in the sense of "of concern") What’s the matter? What is the problem? What is wrong?

(idiomatic) furthermore, or in addition, moreover.

(colloquial) What is wrong? Why is this happening? / (colloquial, possibly dated) What is happening? What is going on? / (colloquial) How are you?

(interrogative, vulgar, slang) An intensive form of what.

(vulgar) Used to express astonishment, shock, incredulity, or disbelief (as a shortened form of expressions such as "What the fuck is going on?", "...are you doing?", "…is this?" "…is it" or "...is that?").

(idiomatic, Britain, colloquial) An intensified version of what or huh.

(idiomatic) What is wrong? What's the problem? / (dated) What's happening? What's the news?

(idiomatic, informal) A greeting, similar to how are you?; what's happening?; what's up?; what's new?

(idiomatic) What is the purpose or advantage of