Researchers analyzed the metabolic pathways of several substituted amphetamines to assess their toxicity.

Researchers identified a substituted amphetamine in the wastewater samples, indicating illicit drug use in the area.

After his doctor warned him about high blood pressure, he switched to a salt substitute when seasoning his food.

Many people with high blood pressure use salt substitutes to reduce sodium intake.

Many philosophers have questioned whether the principle of substitutivity holds when applied to identity statements involving fictional characters.

In organic chemistry lectures, the professor explained that substitutive nomenclature — where a functional group is incorporated as a prefix or suffix to a parent compound's name, as in trinitrotoluene or benzenesulfonic acid — helps students systematically name complex molecules.

The café offered free substitutions for any item on the breakfast menu, which delighted customers.

The tournament adopted free substitution to allow coaches to rotate players freely throughout each match.

Researchers are testing several blood substitutions in the lab to determine which is safest for emergency transfusions.

The coach immediately called for a blood substitution when the flanker started bleeding, allowing medics to treat him off the field.