(now rare, archaic) Introducing a subordinate clause, frequently with that: "it is not that (the following clause) is not the case".

One cannot change one's nature, no matter how much time passes.

Synonym of all over but the shouting

(humorous) There are plenty of potential romantic/sexual partners available, but many of them are strange or eccentric people.

(basketball) The situation where the ball passes through the net without striking either the rim or the backboard.

In order to achieve something, it is inevitable and necessary that some sacrifices must be made.

One cannot change one's nature, no matter how much time passes.

(Northern England, idiomatic) Used at the end of a sentence to add emphasis.

only

(pharmacology) A local anesthetic.