resiniferatoxin

名詞

不可算名詞

(organic chemistry) A naturally occurring ultrapotent capsaicin analogue (having in its pure form a Scoville heat unit measure of 16,000,000,000) that activates the receptor TRPV1 (aka vanilloid receptor 1 or the capsaicin receptor) in a subpopulation of primary afferent sensory neurons involved in nociception.

日本語の意味

有機化学用語において、天然に存在する非常に強力なカプサイシン類似体。純物質ではスコヴィル熱単位が16,000,000,000にも達し、TRPV1（カプサイシン受容体とも呼ばれる）を活性化することで、痛覚伝達に関与する一次求心性感覚神経の一部に作用する物質。

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Researchers administered resiniferatoxin to activate TRPV1 receptors and study pain signaling in sensory neurons.

研究者たちは、侵害受容に関与する一次求心性感覚ニューロンの一部に存在するTRPV1受容体を活性化する、天然に存在する超強力なカプサイシン類縁体を投与して痛みの信号伝達を研究した。

詳細

意味（1）

(organic chemistry) A naturally occurring ultrapotent capsaicin analogue (having in its pure form a Scoville heat unit measure of 16,000,000,000) that activates the receptor TRPV1 (aka vanilloid receptor 1 or the capsaicin receptor) in a subpopulation of primary afferent sensory neurons involved in nociception.

An exciting recent advance in the vanilloid field has been our discovery that resiniferatoxin (RTX), a naturally occurring diterpene combining structural features of the phorbol ester tumor promoters and of capsaicin (see structures in Fig. 1), functions as an ultrapotent capsaicin analog (4—6) and that the esterification of other phorbol-related diterpenes with homovanillic acid at the C-20 position yields synthetic vanilloids of the RTX class with unique spectra of action (7).

詳細