is there any problem?

Used to emphasize the truth of a characterization

(archaic) Across that.

(simile, colloquial, Yorkshire, Lancashire) Nothing is as strange as people can be; people can behave very oddly sometimes.

To arrive at a destination. / (idiomatic) To succeed after a lengthy attempt.

The specified thing exists, physically or abstractly.

An informal greeting.

In, at or to various places; in one place and another. / (uncommon) From time to time; intermittently, occasionally.

You have done it, or are doing it, correctly. / Used to explain or justify one's course of action. / Expressing exasperation.

(colloquial) One cannot run from one's problems indefinitely.