To determine the amount of substance in the sample, the chemist measured the number of moles of the solute present.

In determining the constitutionality of the statute, the court focused on the pith and substance of the law rather than its incidental effects.

Law enforcement officers seized several controlled substances during the traffic stop.

When minnows detected the alarm substances, they swam to deeper water and formed a tighter shoal.

Don't take the shadow for the substance when assessing someone's character based on a few public appearances.

Her argument sounded substanceless in the face of the evidence.

The substancelessness of his arguments became apparent during the debate.

In his lecture on metaphysics, the professor argued that substancehood is what grants an entity its identity over time.