Researchers identified a previously unknown topoisomer of bacterial DNA that influenced replication.

Researchers isolated several topoisomers to study how DNA topology influences gene expression.

During DNA replication, topoisomerization by specialized enzymes relieves supercoiling to ensure accurate copying of the genome.

The team characterized topoisomeric forms of the plasmid to determine how DNA topology affects gene expression.

The drug inhibits topoisomerase, preventing the rapid replication of cancer cells.

Researchers studied how topoisomerases resolve DNA supercoiling during replication.

An increased frequency of topoisomerizations in bacterial chromosomes can relieve torsional stress during rapid cell division.