After prolonged low-frequency stimulation, the neurons began depotentiating, leading to a measurable decrease in synaptic efficacy.

Researchers found that a low-frequency stimulus can depotentiate previously strengthened synapses, erasing the memory trace at the cellular level.

During the recovery period, the hippocampal synapses depotentiated, restoring baseline neuronal responses.

During the experiment, low-frequency stimulation depotentiates the recently strengthened synapses.

The depotentiation observed in the assay suggested that the new compound reduced the signaling effects of the neurotransmitter.

The lab reported several unexpected depotentiations in the hippocampal slices after the drug treatment.