During the recovery period, the hippocampal synapses depotentiated, restoring baseline neuronal responses.

Researchers found that a low-frequency stimulus can depotentiate previously strengthened synapses, erasing the memory trace at the cellular level.

During the experiment, low-frequency stimulation depotentiates the recently strengthened synapses.

The depotentiation observed in the assay suggested that the new compound reduced the signaling effects of the neurotransmitter.

After prolonged low-frequency stimulation, the neurons began depotentiating, leading to a measurable decrease in synaptic efficacy.

The lab reported several unexpected depotentiations in the hippocampal slices after the drug treatment.