Researchers observed that ubiquitins were rapidly attached to damaged proteins to mark them for degradation.

ubiquitin ligases regulate protein turnover by tagging substrates for degradation.

The ubiquitin ligase recognized the misfolded protein and targeted it for proteasomal degradation.

Researchers observed that small ubiquitin-related modifiers accumulate at sites of DNA damage to regulate repair.

The researcher observed that the small ubiquitin-related modifier altered the nuclear localization of the target protein.

The researcher discovered a novel ubiquitinase that selectively targets damaged mitochondrial proteins for degradation.

Ubiquitinases control protein stability by attaching ubiquitin chains that target proteins for degradation.