Fluorescent markers revealed that the receptor-ligand complex accumulates in the endosome before being delivered to lysosomes.

Researchers tracked fluorescently labeled cargo as it passed through endosomes toward lysosomes.

The receptor was sorted endosomally, directing it toward lysosomal degradation rather than recycling to the plasma membrane.

The researchers observed endosomal trafficking defects in the mutant cells, which impaired receptor recycling.

Researchers observed endosomic vesicle trafficking during the cellular response to stress.