Recent studies demonstrated that Moffatt oxidations are particularly effective for converting secondary alcohols to ketones under mild conditions.

To prepare the aldehyde intermediate, the team used the Moffatt oxidation because it proceeds under mild, non-acidic conditions.

In our lab, we optimized the Pfitzner-Moffatt oxidation to improve yields of the desired aldehyde from the primary alcohol.

Pfitzner-Moffatt oxidations were used to selectively oxidize the secondary alcohols to ketones under mild conditions.