For eſſentiall things are alwaies farre more effectuall then groſſe bee, for confirmation whereof we neede not doubt, that if a man ſhould ſeparate the roſinous and ſulphurous ſubſtance of Tobaccao, and bring it into ſuch a conſiſtence as Opium is, and afterwards giue it vnto ſuch as vſually take Tobacco, they could not poſſibly indure the tenth part ſo much of this as of the leaues, as hath beene alreadie practiſed and tried.