During the total synthesis, the Dötz reaction delivered the target substituted phenol with excellent yield and selectivity.

Recent studies have expanded the scope of Dötz reactions to synthesize complex phenolic frameworks.

In our lab meeting, we discussed several challenging Wulff-Dötz reactions and their recent mechanistic studies.

The Wulff-Dötz reaction efficiently converts an aromatic or vinylic alkoxy pentacarbonyl chromium carbene complex, an alkyne, and carbon monoxide into a Cr(CO)3-coordinated substituted phenol under mild conditions.