English Dictionary

holdase

名詞

A particular kind of molecular chaperone that assists the non-covalent folding of proteins in an ATP-dependent manner. Holdases bind to protein folding intermediates to prevent their aggregation but without directly refolding them.

日本語の意味

ATP依存的に非共有結合でタンパク質の折り畳みを補助する分子シャペロンの一種。ホルダーゼは、タンパク質の折り畳み中間体に結合し、その凝集を防ぐが、直接的な折り畳みの補助は行わない。

In the experiment, the holdase bound transient folding intermediates to prevent aggregation without directly refolding them.

実験では、一時的な折りたたみ中間体に結合して凝集を防ぐ分子シャペロンが、それらを直接再折りたたむことなく機能する様子が観察された。

意味（1）

A particular kind of molecular chaperone that assists the non-covalent folding of proteins in an ATP-dependent manner. Holdases bind to protein folding intermediates to prevent their aggregation but without directly refolding them.

As a part of that network, holdase chaperones are able to communicate with other chaperones in the network, to achieve refolding of misfolded clients.

holdases （ plural ）