Very careful developmental or anatomical investigation may be required to show that the variously-constructed organs of many cormophytes are derived by the metamorphosis of the three primary organs, root, stem, and leaf, and to ascertain with which of these any particular structure is really homologous.

ISO 704 and ISO 1087 prescribe mononymy as highly desirable for standardized terminologies, but as experience shows, individuals in developing disciplines (having unsettled terminology) are rarely able to agree on mononyms.

However, it has been said that thiamine preparations will misflavor the beverages or cause body odor, or that they will be precipitated by tannins or destroyed by traces of SO2 (0–6 mg/l in U.S. beers) during pasteurization or shelf storage.

But in recent years, a group of fringe scientists aided by defense industry insiders has convinced the Pentagon that America's post-9/11 survival depends on developing an isomer bomb. While proponents compare it to the Manhattan Project, opponents point out that independent researchers have not been able to duplicate the results attained by isomer enthusiasts, and that many assumptions behind the bomb contradict the laws of physics. Though Congress canceled isomer bomb development in 2004, the Department of Energy found $5 million to continue the research.