They're gaining on you; you'd better hit the gas, now!

Main causes are trauma, infection, atherosclerosis or iatrogenicities [ 2, 3 ].

Apollo 11 landed people on the moon for the first time

The locomotives were labelled 'ugly', 'unsightly' and 'industrial', as their cab fronts were a mass of slats, grooves and blocks (despite the fact that, of course, locomotives are for work - it's not a beauty contest).