The War Office, said Miss Nightingale, is a very slow office, an enormously expensive office, and one in which the Minister's intentions can be entirely negatived by all his sub-departments, and those of each of the sub-departments by every other.

[H]e determined (with an eye rather to heart-interests than to increasing his professional practice) to make, as before, the castle itself his office, studio, and chief abiding place till the works were fairly in progress.

Tungning, one of the most isolated towns in all Manchuria, is four hundred miles east of Harbin. To get there, I went by rail to the border town Progranichnaya, where the Chinese Eastern Railway enters eastern Russia (Siberia), then traveled sixty miles south through wild mountains on the Manchuria-Siberia border, a journey of one day by bus or two days by Russian wagon.[…] At Tungning we found a well-to-do Christian who was the leading carpenter of the town. He was known by all as a believer. Although the population of Tungning was large (40,000), no one knew of any missionary or other Christian worker having ever been there. They did know of some Korean Christians in a village nearby. Tungning was a real frontier town, and the only one in all China where we had seen no heathen temple.]

The neolignan grandidisin also reduced MNPCE frequency in mice treated with cyclophosphamide, a known genotoxic agent [33 ].