transactivities

To identify whether the transactivities of COX-2 were induced with IL-8 over-expression, Huh7 cells were co-transfected with IL-8 expression vectors, pCMV-IL-8-Myc, and pCOX-2-Luc. As shown in Fig 3A, IL-8 significantly induced COX-2 promoter activity in a dose-dependent manner.