Prior to a bottleneck (typically a population bottleneck)

(transitive) To render aseptic; to sterilize; to cleanse of pathogenic materials.

(pharmacology) An antithrombotic agent binding to the GPIbα subunit of the glycoprotein Ib-IX-V complex, purified from the venom of the sharp-nosed viper (Deinagkistrodon acutus).

Criticism of oneself.