Your remark is irrelevant to our argument.

What does your remark have to do with the subject we are talking about?

We deplore your cruelty to animals.

Your proposal is worthy of being considered.

Your subscription expires with the June issue.

Your goodwill sank into my heart.

I have to put down your new address.

Your analysis of the situation is accurate.

If your boss "sacks" you, it means you're fired.

I can't fathom what you said.