The Great Depression was the worst financial event in US history.

But Missy places Ludacris' performance in the rap after her two verses and just before the ending chorus in which she declares over and over that she does not want a one minute man, placement which could be read to suggest that Missy is prompting Ludacris to defend his persona against charges of sexual inadequacy.

I sincerely believe she should kiss us all, it's her princessly duty.

This program is also capable of BLASTing sequencing results and works with most automated sequencing formats, alleviating the need for conversion of PC-based files.