Since it is easy to undershift or overshift, each lever must be adjusted manually to its optimal position on the cog or chainring.

[T]he common man, who until then had suffered dumbly and indolently, might be forced to pay attention. Finding, perhaps, that there is no solution either in politics or in any existing religion, he may cling to the diagnosis of the last and quackest of his doctors: he may believe that art can save himself and the world.

Don Quixote undertook to redress the bodily wrongs of the world, but the redressment of mental vagaries would be an enterprise more than Quixotic

Our data provide an important platform for future investigations aimed to characterize the concrete roles of specific miRNAs and other regulatory smRNAs including piRNAs in penile cancer initiation, progression, invasion and also effective theragnosis.