The fact that the measurements were done manually makes it highly unlikely to have enough sensitivity and reproducibility to detect reliable intertreatment changes in the short period of follow-up, particularly for segments such as the internal and external carotid artery which are very difficult to visualize and cannot clearly be detected in all patients.

It is undeniable that Malcolm was a beacon of huge strength in his lifetime. He could connect with swaths of people when others could not.

But, with United fans in celebratory mood as it appeared their team might snatch glory, they faced an anxious wait as City equalised in stoppage time.

Histamin, an active principle of ergot, is a base produced by splitting off carbon dioxine from histidin by chemical or bacterial agents.