However, more work is needed to determine whether methylation in this locus is involved in the etiopathology of mania.

“In a paper in the Forum of December, 1892, by Mr. Jacob Riis, on the special needs of the poor in New York, he says: ‘For many years it has been true of New York that one-tenth of all who die in this great and wealthy city are buried in the pottersfield. Of the 382, 530 interments recorded in the past decade, 37,966 were in the pottersfield,’ and Mr. Riis proceeds to hint at the fact known to all students of social conditions who personally investigate poverty in the great cities, that this pottersfield gauge, terribly significant though it be, is no adequate measure by which to estimate the poverty problem of a great city.

Philip Miles, defending, said: This was a single instance, there was no allegation of continuing behaviour over a long period of time.

He was a large fleshy man, weighing at least two hundred pounds, and he quickly became a faithful representation of a quivering jelly-mountain of fat.