The TGF/Smad pathway appeared to play a role in this process, and we hypothesize that high-glucose peritoneal dialysis solutions, particularly bioincompatible peritoneal dialysis solutions, activate this pathway which may contribute to the observed changes in the peritoneum.

“Uck,” he said. “I mean, you... you've got to be kidding.”

I am not interested in the why, but in the how.

Sally Taylor and friends did, and produced Grape Expeditions in France (Springfield Books, £5.95) an introduction to the “bicyclable wine regions of France”.