Take this medicine half-hourly.

Do you want your brother, father, husband or lover to admire the trousersed female bicycle rider?

Tuj1 immunohistochemistry showed the proximal colon appeared normally ganglionated (Fig 5A and 5Ai ) progressing distally to the hypoganglionated region of transition zone (Fig 5A and 5Aii ) and to the distal-most bowel, which, although showing innervation by extrinsic fibres, lacks an intrinsic ENS (Fig 5A and 5Aiii ).

There is nothing implausible about this, but there will certainly have been cities along the way, most obviously Lan-chou on the Huang-ho River at the southern end of the Kansu corridor, which, assuming that Pegolotti came that way, he would have found impossible to miss.