Of patients with known outcomes, 4697 (78%) had viable, serotypeable isolates from a single IPD episode and 3953 (84%) of these were due to the 20 most frequent serotypes including PCV-13 vaccine serotypes.

Perry can undoubtedly be a pain in the backside but in Friends, Lovers and the Big Terrible Thing he wears his big, bruised heart on his sleeve. The overwhelming sense is of a lonely, disappointed man in desperate need of a hug.

Here he ran out of words, and drew himself up, beard at the high port, shaking his great head while he clasped my hand, and I meditated on the astonishing ease with which strong men of Victorian vintage could be buffaloed into incoherent embarrassment by the mere mention of feminine frailty.

There are a few day-flying exceptions such as hummingbird hawk-moths, silver Ys, cinnabars, scarlet tigers and burnets but, in general, knowledge of moths lags behind that of butterflies.