1591 (date written), William Shakespeare, “The First Part of Henry the Sixt”, in Mr. William Shakespeares Comedies, Histories, & Tragedies…, London: […] Isaac Iaggard, and Ed[ward] Blount, published 1623, OCLC 606515358, (please specify the act number in uppercase Roman numerals, and the scene number in lowercase Roman numerals):

As a result, all three wheelsets derails to the six foot side.

The young doctor pioneered a new life-saving surgical technique.

Both despair and wanhope are generally defined as a complete loss or lack of hope and being overcome by sense of futility or defeat.