Using a Shigella sonnei strain that was genetically modified to produce penta-acylated lipopolysaccharide (LPS) with reduced endotoxicity and to maintain the virulence plasmid encoding for the immunodominant O antigen component of the LPS, scale up of the process to GMP pilot scale was straightforward and gave high yields of GMMA with required purity and consistent results.

Until recently, the project risk management community discussed but did not have means for addressing unk unks. However, a recent book addresses unk unks and provides approaches for addressing them.

When you are finished with circle time, dismiss your children by helping each one do a roly-poly roll (a somersault) and roll away to their next activity.

The trail with its wide grassy areas was the perfect spot for pongee sticks. Lou looked up from the prone position and focused on a pongee stick right before his eyes, and then he noticed another, then another, and another.