For the few chemical compounds where the histogenesis of renal adenocarcinoma has been studied in detail, karyomegaly is often seen as one of the earliest cellular alterations which can be related to carcinogen exposure.

The underlying pathological aberrations comprise insulin resistance and bihormonal dysfunction of the pancreatic α- and β-cells.

Philosophy is often divided into five major branches: logic, metaphysics, epistemology, ethics and aesthetics.

Alternatively it may mean that a perfunctory search is enough to ensure that a purchase is acceptable, so less search is carried out.