to be shattered in intellect; to have shattered hopes, or a shattered constitution

Unable to leave, the only course of action for the Doomguy is to fight through the base.

To rule out secondary causes of erythrocytosis, such as congenital heart disease with a right to left shunt, a transthoracic echocardiogram was performed, which showed normal left ventricular function with an apical area of dyskinesis and a large left ventricular apical thrombus measuring 3.0 cm×2.0 cm.

He always finished first in the annual Hallowe'en neep lantern competition though it was meant to be done by the pupils themselves.