(colloquial, sometimes rhetorical question) What is wrong with. / (colloquial, sometimes rhetorical question) What is the reason for.

(transitive) To bewail; to weep bitterly over; to feel sorrow for. / (transitive) To condemn; to express strong disapproval of. / (obsolete) To regard as hopeless; to give up.

(colloquial, transitive) To make flustered.

(transitive, informal) To surpass in stupidity.