neoadjuvantly

Therapeutic options for desmoids are (radical) surgical resection with a wide resection margin, radiation (50-60 Gy, as single treatment postoperatively or neoadjuvantly), chemotherapy (antracyclines, vinca alkaloids, methotrexate, dacarbazine, temozolomide), tyrosine kinase inhibitors (imatinib, sorafenib), and also non-cytotoxic medical therapies such as high-dose antiestrogens and non-steroidal anti-inflammatory drugs (NSAIDs).