Clinical resistance to the Bcr-Abl inhibitor imatinib is a critical problem in treating CML. This study investigated the antitumor effect and mechanism of MPT0B169, a new antitubulin agent, in K562 CML cells and their derived imatinib-resistant cells, IMR2 and IMR3.

In between what she called the goody-good or frilly-knickers Hollywood films, she bit off some more demanding parts back home.

Attempts by Waterloo signalmen to clear the points by power operation eventually exhausted point motor batteries, which are fed by trickle chargers, and a blown fuse accentuated the problem; thus, even when the points had been cleared of ice, no power was available to operate them until the batteries were sufficiently recharged.

As a long pig! I exclaimed in surprise; why what does he mean by that? He means somethin' very unpleasant, answered Bill with a frown.