An illustrative example is the Tachyplesin family, which comprises potent antimicrobial peptides isolated from hemocytes of horseshoe crab[ 135 ] that proved useful as inhibitors of HIV replication.[ 136 ] Tachyplesins are amphiphatic peptides containing two disulfide bridges that lock the antiparallel β-hairpin conformation.[ 137 ] The presence of these disulfide bonds in natural products underlines the relevance of macrocyclization for the stabilization of isolated β-hairpin structures.

She gave me a wise-apple smirk and asked, And how are things at YOUR house?

The swankies lap thro' mire and slike, Wow ! as their heads did birr: They yowph'd the ba' frae dike to dike, Wi ' unco' speed and virr,

So I took a great dry gourd and, cutting open the head, scooped out the inside and cleaned it; after which I gathered grapes from a vine which grew hard by and squeezed them into the gourd, till it was full of the juice. Then I stopped up the mouth and set in the sun, where I left it for some days, until it became strong wine; and every day I used to drink of it, to comfort and sustain me under my fatigues with that from froward and obstinate fiend; and as often as I drank myself drunk, I forgot my troubles and took new heart.